Endometrial cancer is a disease of the affluent, developed world, where epidemiological
studies have shown that≥ 40% of its incidence can be attributed to excess body weight. An�…

Estradiol production is most commonly thought of as an endocrine product of the ovary;
however, there are many tissues that have the capacity to synthesize estrogens from�…

One of the greatest challenges facing human geneticists is the identification and
characterization of susceptibility genes for common complex multifactorial human diseases�…

Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the�…

Obesity is known to increase the risk for cancer of the reproductive tract in women. The
mechanism underlying this association can be explained by increased estrogenic stimulus�…

Estrogens are eliminated from the body by metabolic conversion to estrogenically inactive
metabolites that are excreted in the urine and/or feces. The first step in the metabolism of�…

A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase,
inhibition of which effectively eliminates estrogen production. Aromatase inhibitors�…

ABSTRACT Serum estrone (E,) and 17β-estradiol (E2) were noted to be 2-fold elevated in a
group of morbidly obese men. Urinary E1 and E2 production rates were elevated in�…

Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and
therefore has a pivotal role in regulating the formation of biologically active steroids. The�…

Recent evidence demonstrating an increased fracture risk among obese individuals
suggests that adipose tissue may negatively impact bone health, challenging the traditional�…