Tumour blood vessels differ from their normal counterparts for reasons that have received
little attention. We report here that they are of at least six distinct types, we describe how�…

Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of�…

Quinoline (1-azanaphthalene) is a heterocyclic aromatic nitrogen compound characterized
by a double-ring structure that contains a benzene ring fused to pyridine at two adjacent�…

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other�…

The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions�…

VEGF can be secreted in multiple isoforms with variable affinity for extracellular proteins and
different abilities to induce vascular morphogenesis, but the molecular mechanisms behind�…

Angiogenesis—one of the hallmarks of cancer—has emerged as a valid therapeutic target in
oncology. The VEGF system represents a key mediator of tumor-initiated angiogenesis and�…

Angiogenesis is a hallmark of tumor development and metastasis and is now a validated
target for cancer treatment. However, the survival benefits of antiangiogenic drugs have thus�…

Tumor blood vessel formation is a key process for tumor expansion. Tumor vessels are
abnormal and differ from normal vessels in architecture and components. Besides oxygen�…

Vascular endothelial growth factor A (VEGF-A) is well known for its key roles in blood vessel
growth. Although most studies on VEGF and VEGF receptors have been focused on their�…