The hippocampus and its extended network contribute to encoding and recall of episodic
experiences. Drawing from recent anatomical, physiological, and behavioral studies, we�…

There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective�…

INTRODUCTION Learning induces a dynamic reorganization of brain circuits but the
neuronal mechanisms underlying this process are not well understood. Interregional gamma�…

Animals associate cues with outcomes and update these associations as new information is
presented. This requires the hippocampus, yet how hippocampal neurons track changes in�…

Alzheimer's disease (AD) is characterized by the accumulation of the tau protein in neurons,
neurodegeneration and memory loss. However, the role of non-neuronal cells in this chain�…

Memory, defined as the storage and use of learned information in the brain, is necessary to
modulate behavior and critical for animals to adapt to their environments and survive�…

Queuosine (Q) is a modified nucleoside at the wobble position of specific tRNAs. In
mammals, queuosinylation is facilitated by queuine uptake from the gut microbiota and is�…

Neonicotinoids are a class of insecticides that exert their effect through a specific action on
neuronal nicotinic acetylcholine receptors (nAChRs). The success of these insecticides is�…

Adult hippocampal neurogenesis (AHN) represents a remarkable form of neuroplasticity that
has increasingly been linked to the stress response in recent years. However, the�…

Episodic memory formation and recall are complementary processes that rely on opposing
neuronal computations in the hippocampus. How this conflict is resolved in hippocampal�…