Body weight impacts on both bone turnover and bone density, and is therefore an important
risk factor for vertebral and hip fractures, ranking in importance alongside that of age. The�…

Body weight impacts both bone turnover and bone density, making it, therefore, an important
risk factor for vertebral and hip fractures and ranking it alongside age in importance. The�…

Glucagon-like peptide-2 (GLP-2) is a 33-amino-acid proglucagon-derived peptide secreted
from enteroendocrine L cells. GLP-2 circulates at low basal levels in the fasting period, and�…

Intestinal failure (IF) can be defined as the reduction of functional gut mass below the
minimal amount necessary for digestion and absorption adequate to satisfy the nutrient and�…

Intestinal failure is a condition requiring the use of parenteral nutrition as long as it persists.
Causes of severe protracted intestinal failure include short bowel syndrome, congenital�…

Collagen type I fragments, reflecting bone resorption, and release of gut hormones were
investigated after a meal. Investigations led to a dose escalation study with glucagon like�…

Bone homeostasis displays a circadian rhythm with increased resorption during the night
time as compared to day time, a difference that seems—at least partly—to be caused by food�…

Background Home parenteral nutrition (HPN) is currently the management of choice for
patients with chronic intestinal failure. Aim To summarise the major issues in delivering long�…

The actions of the structurally related proglucagon-derived peptides (PGDPs)—glucagon,
glucagon-like peptide (GLP)-1 and GLP-2—are focused on complementary aspects of�…

Background & Aims: The gut-derived peptide glucagon-like peptide 2 (GLP-2) has been
suggested as a potential drug candidate for the treatment of various intestinal diseases�…