Background Antiretroviral drugs reduce viral replication and can reduce mother‐to‐child
transmission of HIV either by lowering plasma viral load in pregnant women or through post�…

Despite advances in antiretroviral therapy that have revolutionized HIV disease
management, effective control of the HIV infection pandemic remains elusive. Beyond the�…

The detection of mutant spectra within a population of microorganisms is critical for the
management of drug-resistant infections. We performed ultra-deep pyrosequencing to detect�…

Background Transmitted HIV-1 drug resistance can compromise initial antiretroviral therapy
(ART); therefore, its detection is important for patient management. The absence of drug�…

The article presents guidelines from the British HIV Association for the treatment of HIV-1-
infected adults using antiretroviral therapy. It presents data from clinical trials on the�…

Antiretroviral treatment (ART) for HIV is being scaled up rapidly in resource-limited countries.
Treatment options are simplified and standardized, generally with one potent first-line�…

Analysis of HIV drug resistance has identified sites on HIV target genes that convey
resistance to particular classes of agents. These data may be especially important in�…

Background Single-dose nevirapine is the cornerstone of the regimen for prevention of
mother-to-child transmission of human immunodeficiency virus (HIV) in resource-limited�…

Background. Early virological failure of antiretroviral therapy associated with the selection of
drug-resistant human immunodeficiency virus type 1 in treatment-naive patients is very�…

To address drug resistance to HIV-1 non-nucleoside reverse transcriptase inhibitors
(NNRTIs), a series of novel diarylpyrimidine (DAPY) derivatives targeting “tolerant region I”�…