Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty�…

Mineral–microbe interactions play important roles in environmental change, biogeochemical
cycling of elements and formation of ore deposits. Minerals provide both beneficial (physical�…

Mitochondria are essential in most eukaryotes and are involved in numerous biological
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and�…

Immunometabolism explores how the intracellular metabolic pathways in immune cells can
regulate their function under different micro-environmental and (patho-)-physiological�…

The biogenesis of iron–sulfur (Fe/S) proteins in eukaryotes is a multistage,
multicompartment process that is essential for a broad range of cellular functions, including�…

Iron is an essential redox element that functions as a cofactor in many metabolic pathways.
Critical enzymes in DNA metabolism, including multiple DNA repair enzymes (helicases�…

New and provocative insights into the relationships between iron and cancer have been
uncovered in recent years. These include delineation of connections that link cellular iron to�…

Abstract Iron-sulfur (Fe-S) clusters are essential protein cofactors whose biosynthetic defects
lead to severe diseases among which is Friedreich's ataxia caused by impaired expression�…

Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative�…

Iron plays an essential role in normal biological processes: The generation of cellular
energy, oxygen transport, DNA synthesis and repair are all processes that require iron�…