Locus coeruleus: a new look at the blue spot
The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This�…
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This�…
[HTML][HTML] Uncertainty and stress: Why it causes diseases and how it is mastered by the brain
A Peters, BS McEwen, K Friston�- Progress in neurobiology, 2017 - Elsevier
The term 'stress'–coined in 1936–has many definitions, but until now has lacked a
theoretical foundation. Here we present an information-theoretic approach–based on the�…
theoretical foundation. Here we present an information-theoretic approach–based on the�…
Questions and controversies in the study of time-varying functional connectivity in resting fMRI
The brain is a complex, multiscale dynamical system composed of many interacting regions.
Knowledge of the spatiotemporal organization of these interactions is critical for establishing�…
Knowledge of the spatiotemporal organization of these interactions is critical for establishing�…
A contextual binding theory of episodic memory: systems consolidation reconsidered
Episodic memory reflects the ability to recollect the temporal and spatial context of past
experiences. Episodic memories depend on the hippocampus but have been proposed to�…
experiences. Episodic memories depend on the hippocampus but have been proposed to�…
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI�…
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI�…
[HTML][HTML] The power of negative and positive episodic memories
The power of episodic memories is that they bring a past moment into the present, providing
opportunities for us to recall details of the experiences, reframe or update the memory, and�…
opportunities for us to recall details of the experiences, reframe or update the memory, and�…
The locus coeruleus: essential for maintaining cognitive function and the aging brain
Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential�…
hippocampal regions influence cognition. However, brainstem regions play essential�…
[HTML][HTML] The locus coeruleus-norepinephrine system in stress and arousal: unraveling historical, current, and future perspectives
JA Ross, EJ Van Bockstaele�- Frontiers in psychiatry, 2021 - frontiersin.org
Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and�…
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and�…
[HTML][HTML] Novelty and dopaminergic modulation of memory persistence: a tale of two systems
Adaptation to the ever-changing world is critical for survival, and our brains are particularly
tuned to remember events that differ from previous experiences. Novel experiences induce�…
tuned to remember events that differ from previous experiences. Novel experiences induce�…
[HTML][HTML] Rapid reconfiguration of the functional connectome after chemogenetic locus coeruleus activation
The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates
many fundamental brain functions. Studies in humans have suggested that strong LC�…
many fundamental brain functions. Studies in humans have suggested that strong LC�…