Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-
inflammation, acute respiratory distress syndrome, and multiple organ failure. Cytokine�…

Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical
syndrome related to the host response to infection. The severity of infections is due to an�…

With more than 81 000 deaths worldwide from coronavirus disease 2019 (COVID-19) by
April 8, 2020, 1 it is incumbent on researchers to accelerate clinical trials of any readily�…

There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of�…

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema�…

Severe sepsis is almost invariably associated with systemic activation of coagulation. There
is ample evidence that demonstrates a wide-ranging cross-talk between hemostasis and�…

Sepsis is the leading cause of death in critically ill patients in the United States. Yet the
individual host response to septicemia is variable, depending on the patient's immune�…

An ongoing global pandemic of viral pneumonia (coronavirus disease [COVID-19]), due to
the virus SARS-CoV-2, has infected millions of people and remains a threat to many more�…

Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by
widespread intravascular activation of coagulation that can be caused by infectious insults�…

This maxim, formulated in 1687 by Sir Isaac Newton [1] in his Philosophiae Naturalis
Principia Mathematica, is one of the fundamental principles of science. Biological systems�…