Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary�…

CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC
domain that play an important role in immune system cells, such as CD4+ and CD8+�…

Despite the resounding clinical success in cancer treatment of antibodies that block the
interaction of PD1 with its ligand PDL1, the mechanisms involved remain unknown. A major�…

Combinatorial clinical trials of PARP inhibitors with immunotherapies are ongoing, yet the
immunomodulatory effects of PARP inhibition have been incompletely studied. Here, we�…

Glioblastoma (GBM) is the most aggressive primary malignant brain cancer and urgently
requires effective treatments. Chimeric antigen receptor T (CAR-T) cell therapy offers a�…

KRAS is the most frequently mutated human oncogene, and KRAS inhibition has been a
longtime goal. Recently, inhibitors were developed that bind KRASG12C-GDP and react�…

The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis,
with various components being involved in tumor suppression and tumor growth. A�…

Cold tumor microenvironment (TME) marked with low effector T cell infiltration leads to weak
response to immune checkpoint inhibitor (ICI) treatment. Thus, switching cold to hot TME is�…

Over half of breast-cancer-related deaths are due to recurrence 5 or more years after initial
diagnosis and treatment. This latency suggests that a population of residual tumor cells can�…

The role of neutrophils in bone regeneration remains elusive. In this study, it is shown that
intramuscular implantation of interleukin‐8 (IL‐8)(commonly recognized as a chemotactic�…