The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed�…

The genomic integrity of every organism is constantly challenged by endogenous and
exogenous DNA-damaging factors. Mutagenic agents cause reduced stability of plant�…

Alterations in DNA repair pathways are common in tumors and can result in characteristic
mutational signatures; however, a specific mutational signature associated with somatic�…

Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to�…

Fe–S clusters are partners in the origin of life that predate cells, acetyl-CoA metabolism,
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base�…

G4 motifs are greatly enriched near promoters, suggesting that quadruplex structures may
be targets of transcriptional regulation. Here we show, by ChIP-Seq analysis of human cells�…

The SIBYLS beamline (12.3. 1) of the Advanced Light Source at Lawrence Berkeley
National Laboratory, supported by the US Department of Energy and the National Institutes�…

Transcription factor IIH (TFIIH) is essential for both transcription and nucleotide excision
repair (NER). DNA lesions are initially detected by NER factors XPC and XPE or stalled RNA�…

Formation of the RNA polymerase II (Pol II) open complex (OC) requires DNA unwinding
mediated by the transcription factor TFIIH helicase-related subunit XPB/Ssl2. Because�…

Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from
the genome, yet the mechanisms of NER in humans remain poorly understood. This review�…