Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human�…

Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is�…

Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability�…

Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K�…

Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on�…

Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically�…

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk�…

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for�…

Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population�…

Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases�…