Fat mass and obesity-associated protein (FTO), an RNA N 6-methyladenosine (m 6 A)
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the�…

The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host�…

Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor�…

Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-
faceted senescence-associated secretory phenotype (SASP). Loss of mitochondrial function�…

Primary tumors are drivers of pre-metastatic niche formation, but the coordination by the
secondary organ toward metastatic dissemination is underappreciated. Here, by single-cell�…

Neutrophils, the most abundant type of leukocytes in blood, can form neutrophil extracellular
traps (NETs). These are pathogen-trapping structures generated by expulsion of the�…

Extracellular vesicles (EVs), such as exosomes, can mediate long-distance communication
between cells by delivering biomolecular cargo. It is speculated that EVs undergo back�…

Although the genes essential for life have been identified in less complex model organisms,
their elucidation in human cells has been hindered by technical barriers. We used extensive�…

Summary R-2-hydroxyglutarate (R-2HG), a metabolite produced by mutant isocitrate
dehydrogenases (IDHs), was recently reported to exhibit anti-tumor activity. However, its�…

Cancers arise through the accumulation of genetic and epigenetic alterations that enable
cells to evade telomere-based proliferative barriers and achieve immortality. One such�…