[HTML][HTML] A shared neural basis underlying psychiatric comorbidity
Recent studies proposed a general psychopathology factor underlying common
comorbidities among psychiatric disorders. However, its neurobiological mechanisms and�…
comorbidities among psychiatric disorders. However, its neurobiological mechanisms and�…
Identification of neurobehavioural symptom groups based on shared brain mechanisms
A Ing, PG S�mann, C Chu, N Tay, F Biondo…�- Nature human�…, 2019 - nature.com
Most psychopathological disorders develop in adolescence. The biological basis for this
development is poorly understood. To enhance diagnostic characterization and develop�…
development is poorly understood. To enhance diagnostic characterization and develop�…
A transdiagnostic network for psychiatric illness derived from atrophy and lesions
Psychiatric disorders share neurobiology and frequently co-occur. This neurobiological and
clinical overlap highlights opportunities for transdiagnostic treatments. In this study, we used�…
clinical overlap highlights opportunities for transdiagnostic treatments. In this study, we used�…
A connectome-wide functional signature of transdiagnostic risk for mental illness
Background High rates of comorbidity, shared risk, and overlapping therapeutic
mechanisms have led psychopathology research toward transdiagnostic dimensional�…
mechanisms have led psychopathology research toward transdiagnostic dimensional�…
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa…�- Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart�…
pleiotropic genetic architecture. However, little is known about how genetic variants impart�…
[HTML][HTML] Linked dimensions of psychopathology and connectivity in functional brain networks
Neurobiological abnormalities associated with psychiatric disorders do not map well to
existing diagnostic categories. High co-morbidity suggests dimensional circuit-level�…
existing diagnostic categories. High co-morbidity suggests dimensional circuit-level�…
Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits
The genetic architecture of psychiatric disorders is characterized by a large number of small-
effect variants located primarily in non-coding regions, suggesting that the underlying causal�…
effect variants located primarily in non-coding regions, suggesting that the underlying causal�…
A framework for the investigation of rare genetic disorders in neuropsychiatry
De novo and inherited rare genetic disorders (RGDs) are a major cause of human morbidity,
frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies�…
frequently involving neuropsychiatric symptoms. Recent advances in genomic technologies�…
Identifying biological markers for improved precision medicine in psychiatry
EB Quinlan, T Banaschewski, GJ Barker…�- Molecular�…, 2020 - nature.com
Mental disorders represent an increasing personal and financial burden and yet treatment
development has stagnated in recent decades. Current disease classifications do not reflect�…
development has stagnated in recent decades. Current disease classifications do not reflect�…
Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development
Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental
illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic�…
illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic�…