[HTML][HTML] The role of microRNA in the pathogenesis of diabetic nephropathy

J Szostak, A Gorący, D Durys, P Dec…�- International Journal of�…, 2023 - mdpi.com
Diabetic nephropathy is one of the most common and severe complications of diabetes
mellitus, affecting one in every five patients suffering from diabetes. Despite extensive�…

[HTML][HTML] p53 and myofibroblast apoptosis in organ fibrosis

K McElhinney, M Irnaten, C O'Brien�- International Journal of Molecular�…, 2023 - mdpi.com
Organ fibrosis represents a dysregulated, maladaptive wound repair response that results in
progressive disruption of normal tissue architecture leading to detrimental deterioration in�…

[HTML][HTML] N6-methyladenosine RNA methylation in diabetic kidney disease

J Huang, F Yang, Y Liu, Y Wang�- Biomedicine & Pharmacotherapy, 2024 - Elsevier
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes, and
hyperglycemic memory associated with diabetes carries the risk of disease occurrence�…

SEMA7a primes integrin α5β1 engagement instructing fibroblast mechanotransduction, phenotype and transcriptional programming

P Hu, AE Miller, CR Yeh, GC Bingham, M Civelek…�- Matrix Biology, 2023 - Elsevier
Integrins are cellular receptors that bind the extracellular matrix (ECM) and facilitate the
transduction of biochemical and biophysical microenvironment cues into cellular responses�…

Irisin ameliorates diabetic kidney disease by restoring autophagy in podocytes

W Lai, D Luo, Y Li, Y Li, Q Wang, Z Hu, Z Ye…�- The FASEB�…, 2023 - Wiley Online Library
Many studies have highlighted the importance of moderate exercise. While it can attenuate
diabetic kidney disease, its mechanism has remained unclear. The level of myokine irisin in�…

[HTML][HTML] Long non-coding RNA lncMGC mediates the expression of TGF-β-induced genes in renal cells via nucleosome remodelers

M Kato, Z Chen, S Das, X Wu, J Wang, A Li…�- Frontiers in Molecular�…, 2023 - frontiersin.org
Background: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play key roles in
diabetic kidney disease (DKD). The miR-379 megacluster of miRNAs and its host transcript�…

MicroRNA-217-5p triggers dopaminergic neuronal degeneration via autophagy activation under Atrazine exposure

B Li, Y Jiang, T Wang, W Liu, X Chen, J He, Z Du…�- Environmental�…, 2024 - Elsevier
Atrazine (ATR) is a widely used agricultural herbicide, and its accumulation in soil and water
can cause various environmental health problems. ATR has neurotoxic effects on�…

[HTML][HTML] Luteolin improves nephropathy in hyperglycemic rats through anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms

LY Chen, HL Cheng, CK Liao, YH Kuan…�- Journal of Functional�…, 2023 - Elsevier
Hyperglycemia can also induce the production of free radicals and the progression of
inflammatory reactions. The aim of this study is to explore the potential anti-oxidant and anti�…

[HTML][HTML] Identification of altered miRNAs and their targets in placenta accreta

JM Murrieta-Coxca, E Barth…�- Frontiers in�…, 2023 - frontiersin.org
Placenta accreta spectrum (PAS) is one of the major causes of maternal morbidity and
mortality worldwide with increasing incidence. PAS refers to a group of pathological�…

The exciting future for scleroderma: what therapeutic pathways are on the horizon?

JHW Distler, G Riemekasten…�- Rheumatic Disease�…, 2023 - rheumatic.theclinics.com
There has been major progress in understanding pathogenic mechanisms in systemic
sclerosis (SSc) at a molecular and cellular level. This has permitted key pathways�…