Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate�…

The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating�…

The hippocampus and its associated cortical regions in the medial temporal lobe play
essential roles when animals form a cognitive map and use it to achieve their goals. As the�…

Episodic memory involves learning and recalling associations between items and their
spatiotemporal context. Those memories can be further used to generate internal models of�…

Neuronal networks with strong recurrent connectivity provide the brain with a powerful
means to perform complex computational tasks. However, high-gain excitatory networks are�…

Several types of neurons involved in spatial navigation and memory encode the distance
and direction (that is, the vector) between an agent and items in its environment. Such�…

When exploring new environments animals form spatial memories that are updated with
experience and retrieved upon re-exposure to the same environment. The hippocampus is�…

The hippocampus and its extended network contribute to encoding and recall of episodic
experiences. Drawing from recent anatomical, physiological, and behavioral studies, we�…

Remembering the visual features of oneself is critical for self-recognition. However, the
neural mechanisms of how the visual self-image is developed remain unknown because of�…

Dysregulation in contextual processing is believed to affect several forms of
psychopathology, such as post-traumatic stress disorder (PTSD). The dentate gyrus (DG), a�…