[HTML][HTML] Cognitive impairment in people with epilepsy

A Novak, K Vizjak, M Rakusa�- Journal of Clinical Medicine, 2022 - mdpi.com
People with epilepsy frequently have cognitive impairment. The majority of cognitive
problems is influenced by a variety of interlinked factors, including the early onset of�…

[HTML][HTML] Mechanisms for cognitive impairment in epilepsy: moving beyond seizures

MR Khalife, RC Scott, AE Hernan�- Frontiers in neurology, 2022 - frontiersin.org
There has been a major emphasis on defining the role of seizures in the causation of
cognitive impairments like memory deficits in epilepsy. Here we focus on an alternative�…

Paediatric epilepsy and cognition

S Auvin�- Developmental Medicine & Child Neurology, 2022 - Wiley Online Library
Cognitive comorbidities are more frequent in children with epilepsy than in the general
population. The cognitive function of children with epilepsy should be appropriately�…

Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition

M Dubey, M Pascual-Garcia, K Helmes, DD Wever…�- elife, 2022 - elifesciences.org
Abstract Parvalbumin-positive (PV+) γ-aminobutyric acid (GABA) interneurons are critically
involved in producing rapid network oscillations and cortical microcircuit computations, but�…

Spatial learning impairments and discoordination of entorhinal‐hippocampal circuit coding following prolonged febrile seizures

ML Kloc, Y Chen, JM Daglian, GL Holmes…�- …, 2023 - Wiley Online Library
How the development and function of neural circuits governing learning and memory are
affected by insults in early life remains poorly understood. The goal of this study was to�…

Altered sleep microarchitecture and cognitive impairment in patients with temporal lobe epilepsy

AC Bender, A Jaleel, KR Pellerin, S Moguilner…�- Neurology, 2023 - AAN Enterprises
Background and Objectives To investigate the spatiotemporal characteristics of sleep
waveforms in temporal lobe epilepsy (TLE) and examine their association with cognition�…

Hippocampal interictal spikes during sleep impact long‐term memory consolidation

I Lambert, E Tramoni‐Negre, S Lagarde…�- Annals of�…, 2020 - Wiley Online Library
Objective Non‐rapid eye movement (NREM) sleep is supposed to play a key role in long‐
term memory consolidation transferring information from hippocampus to neocortex�…

[HTML][HTML] Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum

CP Lisgaras, HE Scharfman�- Neurobiology of disease, 2023 - Elsevier
Interictal spikes (IIS) are a common type of abnormal electrical activity in Alzheimer's
disease (AD) and preclinical models. The brain regions where IIS are largest are not known�…

Temporal lobe interictal spikes disrupt encoding and retrieval of verbal memory: A subregion analysis

L Camarillo‐Rodriguez, I Leenen, Z Waldman…�- …, 2022 - Wiley Online Library
Objective The medial temporal lobe (MTL) encodes and recalls memories and can be a
predominant site for interictal spikes (IS) in patients with focal epilepsy. It is unclear whether�…

Accelerated long‐term forgetting in focal epilepsy: Do interictal spikes during sleep matter?

I Lambert, E Tramoni‐Negre, S Lagarde, F Pizzo…�- …, 2021 - Wiley Online Library
Accelerated long‐term forgetting (ALF) is a particular form of amnesia mostly encountered in
focal epilepsy, particularly in temporal lobe epilepsy. This type of memory loss is�…