Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model
Abstract Background and Aim Several epidemiological studies have shown that coffee
intake attenuates the progression of liver fibrosis; however, the mechanism is unclear. Aims
We investigated the direct effects of caffeine on hepatic stellate cells (HSC s) and assessed
whether caffeine attenuated intrahepatic fibrosis in rat model of liver cirrhosis. Methods
Human hepatic stellate cell line, an immortalized human HSC s line, was used in in vitro
assay system. Cell migration and proliferation were assessed in presence of various�…
intake attenuates the progression of liver fibrosis; however, the mechanism is unclear. Aims
We investigated the direct effects of caffeine on hepatic stellate cells (HSC s) and assessed
whether caffeine attenuated intrahepatic fibrosis in rat model of liver cirrhosis. Methods
Human hepatic stellate cell line, an immortalized human HSC s line, was used in in vitro
assay system. Cell migration and proliferation were assessed in presence of various�…
Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model.
SSG Shim SungGon, JDW Jun DaeWon… - 2013 - cabidigitallibrary.org
Abstract Background and Aim: Several epidemiological studies have shown that coffee
intake attenuates the progression of liver fibrosis; however, the mechanism is unclear. Aims:
We investigated the direct effects of caffeine on hepatic stellate cells (HSCs) and assessed
whether caffeine attenuated intrahepatic fibrosis in rat model of liver cirrhosis. Methods:
Human hepatic stellate cell line, an immortalized human HSCs line, was used in in vitro
assay system. Cell migration and proliferation were assessed in presence of various�…
intake attenuates the progression of liver fibrosis; however, the mechanism is unclear. Aims:
We investigated the direct effects of caffeine on hepatic stellate cells (HSCs) and assessed
whether caffeine attenuated intrahepatic fibrosis in rat model of liver cirrhosis. Methods:
Human hepatic stellate cell line, an immortalized human HSCs line, was used in in vitro
assay system. Cell migration and proliferation were assessed in presence of various�…
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