Objectives: Caffeine consumption is reported to be associated with reduced hepatic fibrosis
in patients with chronic liver diseases. We performed a systematic review and meta-analysis
to assess the association between caffeine consumption and prevalence or hepatic fibrosis
of nonalcoholic fatty liver disease (NAFLD) in observational studies. Methods: We searched
the literature of all languages from PubMed, EMBASE, and the Cochrane library from 1
January 1980 through 10 January 2015. Total caffeine consumption was defined as the�…

Methods: We searched the literatures of all languages from PubMed, EMBASE, and the
Cochrane library from January 1, 1980 through June 10, 2014. Total caffeine consumption
was defined as the daily intake of caffeine (mg/day) from all caffeine-containing products.
Combined and subgroup analyses stratified by study designs, study locations, and type of
caffeine intake were performed. Results: Four cross-sectional and 3 case control studies
with a total of 20,064 subjects were included in the meta-analysis. Among these, three�…