Pulmonary fibrosis can be modeled in animals by intratracheal instillation of FITC, which
results in acute lung injury, inflammation, and extracellular matrix deposition. We have�…

We have previously shown that mice that are genetically deficient in the CCR2 gene
(CCR2−/− mice) are protected from fluorescein isothiocyanate (FITC)-induced lung fibrosis�…

Pulmonary fibrosis is the end point of a chronic inflammatory process characterized by
leukocyte recruitment and activation, fibroblast proliferation, and increased extracellular�…

We have investigated the involvement of chemokine receptor CCR1-positive cells in
bleomycin-induced lung injury, a model of pulmonary fibrosis. After bleomycin challenge in�…

Increasing evidence suggests that the development of pulmonary fibrosis is a Th2-mediated
process. We hypothesized that the CC chemokines that are associated with a Th2 profile�…

CXC chemokine receptor 3 (CXCR3) is the receptor for the IFN-γ–inducible CXC
chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. CXCR3 is expressed on�…

MCP-1, which signals via the CC chemokine receptor 2 (CCR2), is induced in lung fibrosis
that is accompanied by mononuclear cell recruitment and activation of lung fibroblasts. To�…

Macrophage infiltration is implicated in various types of pulmonary fibrosis. One important
pathogenetic process associated with pulmonary fibrosis is injury to basement membranes�…

Rationale: The chemokine receptors CXCR3 and CCR4 have recently been described as
playing a pivotal role in the mouse model of bleomycin-induced fibrosis. Objectives: To�…

We investigated the pathogenic roles of CC chemokine ligand (CCL) 3 and its receptors, CC
chemokine receptor (CCR) 1 and CCR5, in bleomycin (BLM)-induced pulmonary fibrosis�…