BACKGROUND Benign prostatic hyperplasia (BPH) is characterized by a proportional
increase in the size of the stromal compartment of the gland, involving alterations to�…

We have previously demonstrated that peritumoral stromal matrix derived from prostate
cancer patients who relapse after radical surgery contains elevated levels of versican. The�…

Extracellular matrix remodeling has emerged as an important factor in many cancers.
Proteoglycans, including versican (VCAN), are regulated via cleavage by the proteolytic�…

BACKGROUND The aim of this study was to investigate how the expression of genes
regulating angiogenesis is altered when prostate cancer cells progress into androgen�…

BACKGROUND The majority of the overgrowth in benign prostatic hyperplasia (BPH)
specimens is comprised of connective tissue. Factors that control stromal growth in the�…

The production of matrix metalloproteinases (MMPs) by prostatic epithelial and/or
neighboring stromal cells is considered to be a property that gives cells the capability to�…

ADAMTS1 is an extracellular metalloproteinase known to participate in a variety of biological
processes that includes inflammation, angiogenesis, and development of the urogenital�…

Purpose: Generation of a reactive stroma environment occurs in many human cancers and
is likely to promote tumorigenesis. However, reactive stroma in human prostate cancer has�…

Increasing evidence points to an active stromal involvement in cancer initiation and
progression. Cytokines derived from tumor cells are believed to modulate stromal cells to�…

In this study, we examined whether versican, a recognized anti-cell adhesive molecule for
various mesenchymal and nerve cell types, influences prostate cancer cell adhesion to�…