Background High rates of comorbidity, shared risk, and overlapping therapeutic
mechanisms have led psychopathology research toward transdiagnostic dimensional�…

The panoply of cognitive, affective, motivational, and social functions that underpin everyday
human experience requires precisely choreographed patterns of interaction between�…

Background There is considerable interest in a dimensional transdiagnostic approach to
psychiatry. Most transdiagnostic studies have derived factors based only on clinical�…

Converging evidence indicates that groups of patients with nominally distinct psychiatric
diagnoses are not separated by sharp or discontinuous neurobiological boundaries. In�…

Neurobiological abnormalities associated with psychiatric disorders do not map well to
existing diagnostic categories. High co-morbidity suggests dimensional circuit-level�…

Several decades of neuroimaging research in psychiatry have shed light on structural and
functional neural abnormalities associated with individual psychiatric disorders. However�…

Background Psychosis is hypothesized to occur on a spectrum between psychotic disorders
and health in individuals. In the middle of the spectrum are individuals who endorse�…

Neuroimaging studies of psychotic disorders have demonstrated abnormalities in structural
and functional connectivity involving widespread brain networks. However, these group�…

Background The psychosis spectrum (PS) is associated with structural dysconnectivity
concentrated in transmodal cortex. However, understanding of this pathophysiology has�…

Transdiagnostic research has identified a general psychopathology factor—often called the
'p'factor—that accounts for shared variation across internalizing, externalizing, and thought�…