Rationale: There is a limited number of biomarkers to identify different phenotypes in
childhood asthma, most reflecting type 2-inflammation. It is largely unknown whether such�…

It is known that asthma is a heterogeneous entity whose manifestations vary with age. Our
objective was to examine changes in the manifestation of asthma and asthma-related traits�…

Background Childhood asthma is a prevalent condition with potential impact on adult life.
Research Question In a 60-year follow-up study of adults with a history of severe childhood�…

RATIONALE: Persistent inflammation of the airways driven by the overproduction of type 2
(T2) cytokines is a pathobiological feature of asthma in many but not all patients. Identifying�…

Lang A, Mowinckel P, Sachs‐Olsen C, Riiser A, Lunde J, Carlsen K‐H, L�drup Carlsen KC.
Asthma severity in childhood, untangling clinical phenotypes. Pediatr Allergy Immunol 2010�…

PURPOSE: The social and economic impact of asthma is remarkable worldwide. To date,
there have been many unanswered questions about factors related to asthma progression�…

Background Compared with adults, phenotypic characterization of children with asthma is
still limited and it remains difficult to predict which children with asthma are at highest risk for�…

Asthma is a complex disease with a significant inflammatory component characterized by
repeated episodes of exacerbation and inflammatory changes in both large and peripheral�…

Background Studies have shown that airway obstruction and increased bronchial reactivity
are present in early life in children developing asthma, which challenges the dogma that�…

Background Childhood asthma phenotypes reflecting underlying developmental
mechanisms are sought, with little information on asthma phenotypes based on allergic�…