Breathing in mammals is hypothesized to result from the interaction of two distinct oscillators:
the preB�tzinger Complex (preB�tC) driving inspiration and the lateral parafacial region�…

Breathing is vital for survival but also interesting from the perspective of rhythm generation.
This rhythmic behavior is generated within the brainstem and is thought to emerge through�…

Data from perinatal and juvenile rodents support our hypothesis that the preB�tzinger
complex generates inspiratory rhythm and the retrotrapezoid nucleus–parafacial respiratory�…

I provide a personal view of the developments since~ 1986 that underlie the contemporary
view (s) about how the rhythm of breathing is generated and how the pattern of breathing is�…

Inspiration and active expiration are commonly viewed as antagonistic phases of a unitary
oscillator that generates respiratory rhythm. This view conflicts with observations we report�…

Key points This study investigates the effects on ventilation of an excitatory stimulus
delivered in a spatially and temporally precise manner to the inspiratory oscillator, the�…

In the mammalian respiratory central pattern generator, the preB�tzinger complex (preB�tC)
produces rhythmic bursts that drive inspiratory motor output. Cellular mechanisms initiated�…

Key points Contraction of abdominal muscles at the end of expiration during metabolic
challenges (such as hypercapnia and hypoxia) improves pulmonary ventilation. The�…

Breathing behaviour involves the generation of normal breaths (eupnoea) on a timescale of
seconds and sigh breaths on the order of minutes. Both rhythms emerge in tandem from a�…

Key points This study investigates the effects of cholinergic transmission on the expiratory
oscillator, the parafacial respiratory group (pFRG) in urethane anaesthetized adult rats�…