Activation of the p53 signaling pathway by DNA‐damaging agents was originally proposed
to result either in cell cycle checkpoint activation to promote survival or in apoptotic cell�…

The tumor protein TP53 gene, encoding the cellular tumor antigen p53, is the single most
frequently mutated gene in human cancers. p53 plays a central role in responding to DNA�…

Highlights•p53 responses to acute DNA damage signals are dispensable for tumor
suppression.•p53 transcriptional activity is critical for tumor suppression.•p53 responds to�…

The molecular basis for p53-mediated tumor suppression remains unclear. Here, to
elucidate mechanisms of p53 tumor suppression, we use knockin mice expressing an allelic�…

The tumor suppressor p53 regulates different cellular pathways involved in cell survival,
DNA repair, apoptosis, and senescence. However, according to an increasing number of�…

Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy�…

In response to cellular stress signals, the tumour suppressor p53 accumulates and triggers a
host of antineoplastic responses. For instance, DNA damage activates two main p53�…

Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals,
and survive only because they have acquired lesions—such as loss of p53—that prevent or�…

The cellular response to genotoxic stress that damages DNA includes cell cycle arrest,
activation of DNA repair, and in the event of irreparable damage, induction of apoptosis�…

The cells in the human body are continuously challenged by a variety of genotoxic attacks.
Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can�…