Effect of GLP-1 treatment on bone turnover in normal, type 2 diabetic, and insulin-resistant states
B Nuche-Berenguer, P Moreno, P Esbrit…�- Calcified tissue�…, 2009 - Springer
It has been suggested that hormones released after nutrient absorption, such as glucose-
dependent insulinotropic peptide (GIP) and glucagon-like peptide 2 (GLP-2), could be�…
dependent insulinotropic peptide (GIP) and glucagon-like peptide 2 (GLP-2), could be�…
GLP-2 and GIP exert separate effects on bone turnover: a randomized, placebo-controlled, crossover study in healthy young men
K Skov-Jeppesen, MS Svane, C Martinussen…�- Bone, 2019 - Elsevier
Abstract Background Glucagon-like peptide-2 (GLP-2) and glucose-dependent
insulinotropic polypeptide (GIP) both inhibit bone resorption in humans but the underlying�…
insulinotropic polypeptide (GIP) both inhibit bone resorption in humans but the underlying�…
Stable incretin mimetics counter rapid deterioration of bone quality in type 1 diabetes mellitus
SA Mansur, A Mieczkowska, B Bouvard…�- Journal of cellular�…, 2015 - Wiley Online Library
Type 1 diabetes mellitus is associated with a high risk for bone fractures. Although bone
mass is reduced, bone quality is also dramatically altered in this disorder. However, recent�…
mass is reduced, bone quality is also dramatically altered in this disorder. However, recent�…
Effects of GLP‐1 receptor agonists on bone mineral density in patients with type 2 diabetes mellitus: a 52‐week clinical study
T Cai, H Li, L Jiang, H Wang, M Luo…�- BioMed Research�…, 2021 - Wiley Online Library
Introduction. Hypoglycemic drugs affect the bone quality and the risk of fractures in patients
with type 2 diabetes mellitus (T2DM). We aimed to investigate the effects of glucagon‐like�…
with type 2 diabetes mellitus (T2DM). We aimed to investigate the effects of glucagon‐like�…
[HTML][HTML] The impact of glucagon-like peptide-1 on bone metabolism and its possible mechanisms
C Zhao, J Liang, Y Yang, M Yu, X Qu�- Frontiers in endocrinology, 2017 - frontiersin.org
The impact of antidiabetic drugs on bone metabolism is drawing increasing attention due to
the discovery of a correlation between type 2 diabetes mellitus (T2DM) and osteoporosis�…
the discovery of a correlation between type 2 diabetes mellitus (T2DM) and osteoporosis�…
Separate and combined effects of GIP and GLP-1 infusions on bone metabolism in overweight men without diabetes
NC Bergmann, A Lund, LS Gasbjerg…�- The Journal of�…, 2019 - academic.oup.com
Context The gut-derived incretin hormones glucose-dependent insulinotropic polypeptide
(GIP) and glucagon-like peptide 1 (GLP-1) have been suggested to play a role in bone�…
(GIP) and glucagon-like peptide 1 (GLP-1) have been suggested to play a role in bone�…
[HTML][HTML] The impact of glucagon-like peptide 1 receptor agonists on bone metabolism and its possible mechanisms in osteoporosis treatment
B Xie, S Chen, Y Xu, W Han, R Hu, M Chen…�- Frontiers in�…, 2021 - frontiersin.org
Diabetes mellitus and osteoporosis are closely related and have complex influencing
factors. The impact of anti-diabetic drugs on bone metabolism has received more and more�…
factors. The impact of anti-diabetic drugs on bone metabolism has received more and more�…
[HTML][HTML] Glucagon-like peptide-1 attenuates diabetes-associated osteoporosis in ZDF rat, possibly through the RAGE pathway
Y Cheng, P Liu, Q Xiang, J Liang, H Chen…�- BMC Musculoskeletal�…, 2022 - Springer
Background Diabetes-associated osteoporosis are partly caused by accumulation of
advanced glycation endproducts (AGEs). Glucagon-like peptide-1 (GLP-1) has been shown�…
advanced glycation endproducts (AGEs). Glucagon-like peptide-1 (GLP-1) has been shown�…
Glucose-dependent insulinotropic polypeptide inhibits bone resorption in humans
Background: In humans, the pronounced postprandial reduction in bone resorption
(decreasing bone resorption markers by around 50%) has been suggested to be caused by�…
(decreasing bone resorption markers by around 50%) has been suggested to be caused by�…
[HTML][HTML] Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists
G Mabilleau, M Pereira, C Chenu�- Journal of endocrinology, 2018 - joe.bioscientifica.com
Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of
fracture, poor bone healing and other skeletal complications. In addition, some anti-diabetic�…
fracture, poor bone healing and other skeletal complications. In addition, some anti-diabetic�…