How might synaptic dynamics generate synchronous oscillations in neuronal networks? We
address this question in the preB�tzinger complex (preB�tC), a brainstem neural network�…

Hyperventilation is a common feature of disordered breathing. Apnea ensues if CO2 drive is
sufficiently reduced. We tested the hypothesis that medullary raph�, ventral respiratory�…

The respiratory central pattern generator must respond to chemosensory cues to maintain
oxygen (O 2) and carbon dioxide (CO 2) homeostasis in the blood and tissues. To do this�…

The role of inhibitory neurons in the respiratory network is a matter of ongoing debate.
Conflicting and contradicting results are manifold and the question whether inhibitory�…

The pre-B�tzinger complex (preB�tC), an area that is critical for generating breathing
(eupnea), gasps and sighs is continuously modulated by catecholamines. These amines�…

Highlights•Excitatory mechanisms are critical for rhythmicity in respiratory microcircuits.•
Inhibition shapes activity within and between distinct rhythm generators.•Each phase of�…

PreB�tzinger Complex (preB�tC) neurons are postulated to underlie respiratory rhythm
generation. The inspiratory phase of the respiratory cycle in vitro results from preB�tC�…

The generation of neural network dynamics relies on the interactions between the intrinsic
and synaptic properties of their neural components. Moreover, neuromodulators allow�…

Normal breathing in rodents requires activity of glutamatergic Dbx1-derived (Dbx1+)
preB�tzinger Complex (preB�tC) neurons expressing somatostatin (SST). We combined in�…

We investigated whether there is endogenous acetylcholine (ACh) release in the
preB�tzinger Complex (preB�tC), a medullary region hypothesized to contain neurons�…