The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus
N Brockdorff, A Ashworth, GF Kay, VM McCabe…�- Cell, 1992 - cell.com
The Xisf gene maps to the X inactivation center region in both mouse and human, and
previous analysis of the 3'end of the gene has demonstrated inactive X-specific expression�…
previous analysis of the 3'end of the gene has demonstrated inactive X-specific expression�…
The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus
CJ Brown, BD Hendrich, JL Rupert, RG Lafreniere…�- Cell, 1992 - cell.com
X chromosome inactivation in mammalian females results in the cis-limited transcriptional
inactivity of most of the genes on one X chromosome. The X/ST gene is unique among X�…
inactivity of most of the genes on one X chromosome. The X/ST gene is unique among X�…
Evolutionary conservation of possible functional domains of the human and murine XIST genes
BD Hendrich, CJ Brown…�- Human molecular genetics, 1993 - academic.oup.com
The human XIST gene, a candidate for a role in X chromosome inactivation, has recently
been cloned and sequenced, yielding a 17 kb cDNA with no apparent significant, conserved�…
been cloned and sequenced, yielding a 17 kb cDNA with no apparent significant, conserved�…
Identification and characterization of the human XIST gene promoter: implications for models of X chromosome inactivation
BD Hendrich, RM Plenge, HF Willard�- Nucleic acids research, 1997 - academic.oup.com
The XIST gene in both humans and mice is expressed exclusively from the inactive X
chromosome and is required for X chromosome inactivation to occur early in development�…
chromosome and is required for X chromosome inactivation to occur early in development�…
XIST and the mapping of the X chromosome inactivation centre.
SDM Brown - 1991 - cabidigitallibrary.org
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Stabilization and localization of Xist RNA are controlled by separate mechanisms and are not sufficient for X inactivation
CM Clemson, JC Chow, CJ Brown…�- The Journal of cell�…, 1998 - rupress.org
These studies address whether XIST RNA is properly localized to the X chromosome in
somatic cells where human XIST expression is reactivated, but fails to result in X inactivation�…
somatic cells where human XIST expression is reactivated, but fails to result in X inactivation�…
Xist RNA Exhibits a Banded Localization on the Inactive X Chromosome and Is Excluded from Autosomal Material in Cis
SM Duthie, TB Nesterova, EJ Formstone…�- Human molecular�…, 1999 - academic.oup.com
The propagation of X chromosome inactivation is thought to be mediated by the cis-limited
spreading of the nonprotein coding Xist transcript. In this report we have investigated the�…
spreading of the nonprotein coding Xist transcript. In this report we have investigated the�…
Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation
GF Kay, GD Penny, D Patel, A Ashworth, N Brockdorff…�- Cell, 1993 - cell.com
The mouse Xisf gene maps to the X inactivation center (Xic) region and tsexpressed
exclusively from the inactive X chromosome. It is thus a candidate gene for the Xic. We show�…
exclusively from the inactive X chromosome. It is thus a candidate gene for the Xic. We show�…
Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain
JT Lee, N Lu, Y Han�- …�of the National Academy of Sciences, 1999 - National Acad Sciences
Dosage compensation in mammals occurs by X inactivation, a silencing mechanism
regulated in cis by the X inactivation center (Xic). In response to developmental cues, the Xic�…
regulated in cis by the X inactivation center (Xic). In response to developmental cues, the Xic�…
Genetic control of X inactivation and processes leading to X-inactivation skewing.
JW Belmont�- American journal of human genetics, 1996 - ncbi.nlm.nih.gov
Some genes (> 12, so far) escape X inactivation, and, in a survey of cDNAs to identify such
genes, a single unique transcript was identified whose expression is restricted to the inactive�…
genes, a single unique transcript was identified whose expression is restricted to the inactive�…