1. Guinea-pigs on a low, controlled intake of ascorbic acid (0.3 mg/100 g body-weight) were
given daily an oral supplement of L-ascorbic acid (AA) or of D-isoascorbic acid (isoAA)(both�…

1. Male and female guinea-pigs with high tissue concentrations of L-xyloascorbic acid
(ascorbic acid, AA) and male guinea-pigs with high tissue concentrations of D�…

1. Young male and female guinea-pigs of similar age and male guinea-pigs of various ages
were given daily oral supplements of vitamin C (L-xyloascorbic acid)(AA) on a body-weight�…

1. Male, adult guinea-pigs received a scorbutogenic diet and a daily supplement of 1.0 mg
ascorbic acid/100 g body-weight. 2. Restriction of food intake for a period of 17 d resulted in�…

Male guinea pigs received sodium ascorbate solution [equivalent to 1 g ascorbic acid/(kg
body weight� d)] by intraperitoneal injection for 4 wk. During the ascorbic acid treatment�…

Guineapigs on a vitamin C-deficient diet supplemented with ascorbic acid 2 g/kg diet or
without the supplement for 17 days were given by mouth 1 ml of a solution of ascorbic acid-1�…

To test the theory that d-isoascorbic acid (IAA) was not retained by the organs of animals,
guinea pigs were fed a synthetic diet containing ascorbic acid (AA) plus IAA. The�…

The tissue distribution of L-ascorbic acid (AsA) and dehydro-L-ascorbic acid (DAsA) in
guinea pigs injected with DAsA intravenously was examined using high-performance liquid�…

The urinary recovery of ascorbic acid (AA) was examined in 3 subjects when the vitamin was
given as a single 1 g dose in solution (control), as divided doses in solution (0.125 g every�…

Results Figure 1, bottom, shows the average weight response curve of five guinea pigs
maintained on the deficient diet. These animals rapidly decreased in weight and by the end�…