Multiple sclerosis (MS) is the most common cause of non‐traumatic disability in young
adults. The mechanisms underlying neurodegeneration and disease progression are poorly�…

In multiple sclerosis (MS), experimental and ex vivo studies indicate that pathologic intra-
and extracellular sodium accumulation may play a pivotal role in inflammatory as well as�…

Objective Sodium (23Na)-MRI is an emerging imaging technique to investigate in vivo
changes in tissue viability, reflecting neuroaxonal integrity and metabolism. Using an�…

Purpose To quantify brain sodium accumulations and characterize for the first time the
spatial location of sodium abnormalities at different stages of relapsing-remitting (RR)�…

The cascade of inflammatory pathogenetic mechanisms in multiple sclerosis (MS) has no
specific conventional MRI correlates. Clinicians therefore stipulate improved imaging�…

Abstract Sodium MRI (23 Na-MRI) has been used to non-invasively quantify tissue sodium
but has been limited by low spatial resolution. Here we demonstrate for the first time that�…

Sodium magnetic resonance imaging (23Na‐MRI) is a highly promising imaging modality
that offers the possibility to noninvasively quantify sodium content in the tissue, one of the�…

Background: Advanced magnetic resonance imaging (MRI) techniques provide a window
into pathological processes in multiple sclerosis (MS). Nevertheless, to date only few studies�…

Sodium magnetic resonance (MR) imaging in humans has promised metabolic information
that can improve medical management in important diseases. This technology has yet to find�…

Neuro-axonal degeneration occurs progressively from the onset of multiple sclerosis and is
thought to be a significant cause of increasing clinical disability. Several histopathological�…