The activity of the p53 gene product is regulated by a plethora of posttranslational
modifications. An open question is whether such posttranslational changes act redundantly�…

Activation of p53-mediated transcription is a critical cellular response to DNA damage. p53
stability and site-specific DNA-binding activity and, therefore, transcriptional activity, are�…

The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a
sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be�…

p53 promotes tumor suppression through its ability to function as a transcriptional factor and
is activated by posttranslational modifications that include acetylation. Our earlier study�…

Histone deacetylase (HDAC) inhibitors are being investigated as possible adjuvant
therapies for a number of diseases, including cancer. In addition to stabilization of acetylated�…

Acetylation of multiple lysine residues in the p53 plays critical roles in the protein stability
and transcriptional activity of p53. To better understand how p53 acetylation is regulated, we�…

Tumor suppressor p53 functions as a “guardian of the genome” to prevent cells from
transformation. p53 is constitutively ubiquitinated and degradated in unstressed conditions�…

The ability of p53 to induce apoptosis plays an important role in tumor suppression. Here,
we describe a previously unknown posttranslational modification of the DNA-binding�…

P53 is of key importance for the protection of an organism against carcinogenesis. P53
performs this function by the regulation of several cellular processes, the most important of�…

Activation of p53 can occur in response to a number of cellular stresses, including DNA
damage, hypoxia and nucleotide deprivation. Several forms of DNA damage have been�…