XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase
JO Fuss, JA Tainer�- DNA repair, 2011 - Elsevier
Helicases must unwind DNA at the right place and time to maintain genomic integrity or
gene expression. Biologically critical XPB and XPD helicases are key members of the�…
gene expression. Biologically critical XPB and XPD helicases are key members of the�…
[HTML][HTML] Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair
Critical for transcription initiation and bulky lesion DNA repair, TFIIH provides an exemplary
system to connect molecular mechanisms to biological outcomes due to its strong genetic�…
system to connect molecular mechanisms to biological outcomes due to its strong genetic�…
A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor
JM Egly, F Coin�- DNA repair, 2011 - Elsevier
The TFIIH multiprotein complex is organized into a 7-subunit core associated with a 3-
subunit CDK-activating kinase module (CAK). Three enzymatic subunits are present in�…
subunit CDK-activating kinase module (CAK). Three enzymatic subunits are present in�…
TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair
O Kolesnikova, L Radu, A Poterszman�- Advances in Protein Chemistry�…, 2019 - Elsevier
Transcription factor IIH (TFIIH) is a multiprotein complex involved in both eukaryotic
transcription and DNA repair, revealing a tight connection between these two processes�…
transcription and DNA repair, revealing a tight connection between these two processes�…
[HTML][HTML] In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair
S Peissert, F Sauer, DB Grabarczyk, C Braun…�- Nature�…, 2020 - nature.com
The XPD helicase is a central component of the general transcription factor TFIIH which
plays major roles in transcription and nucleotide excision repair (NER). Here we present the�…
plays major roles in transcription and nucleotide excision repair (NER). Here we present the�…
Molecular insights into the recruitment of TFIIH to sites of DNA damage
XPB and XPD subunits of TFIIH are central genome caretakers involved in nucleotide
excision repair (NER), although their respective role within this DNA repair pathway remains�…
excision repair (NER), although their respective role within this DNA repair pathway remains�…
ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities
W Abdulrahman, I Iltis, L Radu…�- Proceedings of the�…, 2013 - National Acad Sciences
The xeroderma pigmentosum group D (XPD) helicase is a subunit of transcription/DNA
repair factor, transcription factor II H (TFIIH) that catalyzes the unwinding of a damaged DNA�…
repair factor, transcription factor II H (TFIIH) that catalyzes the unwinding of a damaged DNA�…
The long unwinding road: XPB and XPD helicases in damaged DNA opening
V Oksenych, F Coin�- Cell cycle, 2010 - Taylor & Francis
The mammalian nucleotide excision repair (NER) pathway removes dangerous bulky
adducts from genomic DNA. Failure to eliminate these lesions can lead to oncogenesis�…
adducts from genomic DNA. Failure to eliminate these lesions can lead to oncogenesis�…
[HTML][HTML] In TFIIH, XPD helicase is exclusively devoted to DNA repair
The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription
and nucleotide excision repair (NER). Mutations in human XPD are associated with several�…
and nucleotide excision repair (NER). Mutations in human XPD are associated with several�…
[HTML][HTML] XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations
Mutations in XPD helicase, required for nucleotide excision repair (NER) as part of the
transcription/repair complex TFIIH, cause three distinct phenotypes: cancer-prone�…
transcription/repair complex TFIIH, cause three distinct phenotypes: cancer-prone�…