EZH2 promotes proliferation and invasiveness of prostate cancer cells
BACKGROUND The transcriptional repressor EZH2 is implicated in control of cell
proliferation in embryonic, immortalized and transformed cells. EZH2 expression in prostate�…
proliferation in embryonic, immortalized and transformed cells. EZH2 expression in prostate�…
Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell lines
BDW Karanikolas, ML Figueiredo, L Wu�- The Prostate, 2010 - Wiley Online Library
BACKGROUND Although most prostate cancers respond well to initial treatments, a fraction
of prostate cancers are more aggressive and will recur and metastasize. At that point, there�…
of prostate cancers are more aggressive and will recur and metastasize. At that point, there�…
Androgens suppress EZH2 expression via retinoblastoma (RB) and p130-dependent pathways: a potential mechanism of androgen-refractory progression of prostate�…
LR Bohrer, S Chen, TC Hallstrom, H Huang�- Endocrinology, 2010 - academic.oup.com
Androgens and the androgen receptor are important for both normal prostate development
and progression of prostate cancer (PCa). However, the underlying mechanisms are not�…
and progression of prostate cancer (PCa). However, the underlying mechanisms are not�…
Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer
Elevation of the chromatin repression factor enhancer of zeste homolog (EZH2) is
associated with progression and poor prognosis in several human cancers including�…
associated with progression and poor prognosis in several human cancers including�…
Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy
X Wu, H Scott, SV Carlsson, DD Sjoberg…�- The�…, 2019 - Wiley Online Library
Background Enhancer of zeste 2 (EZH2) promotes prostate cancer progression. We
hypothesized that increased EZH2 expression is associated with postradiotherapy�…
hypothesized that increased EZH2 expression is associated with postradiotherapy�…
Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre�…
N Melling, E Thomsen, MC Tsourlakis, M Kluth…�- …, 2015 - academic.oup.com
Enhancer of zeste homolog 2 (EZH2) plays an important role in tumor development and
progression by interacting with histone and nonhistone proteins. In the current study, we�…
progression by interacting with histone and nonhistone proteins. In the current study, we�…
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and�…
IM Bachmann, OJ Halvorsen, K Collett…�- Journal of clinical�…, 2006 - ascopubs.org
Purpose EZH2 is a member of the polycomb group of genes and important in cell cycle
regulation. Increased expression of EZH2 has been associated previously with invasive�…
regulation. Increased expression of EZH2 has been associated previously with invasive�…
EZH2 accompanies prostate cancer progression
L Xin�- Nature Cell Biology, 2021 - nature.com
Enhancer of zeste homolog 2 (EZH2) has been shown to promote development of castration-
resistant prostate cancer (CRPC) through various mechanisms. A new study now shows that�…
resistant prostate cancer (CRPC) through various mechanisms. A new study now shows that�…
A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation
Abstract Enhancer of Zeste Homolog 2 (EZH2) and androgen receptor (AR) are crucial
chromatin/gene regulators involved in the development and/or progression of prostate�…
chromatin/gene regulators involved in the development and/or progression of prostate�…
[HTML][HTML] Role of EZH2 in the growth of prostate cancer stem cells isolated from LNCaP cells
K Li, C Liu, B Zhou, L Bi, H Huang, T Lin…�- International journal of�…, 2013 - mdpi.com
Enhancer of zeste homolog 2 (EZH2) plays a crucial role in embryonic and somatic stem
cells for their proliferation and differentiation. However, the roles and underlying�…
cells for their proliferation and differentiation. However, the roles and underlying�…
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