Cellular constituents of the alveolar-capillary wall may be key participants in the recruitment
of polymorphonuclear leukocytes to the lung through the generation of the novel neutrophil�…

The capacity of cells of the human bronchial epithelium to express the gene for interleukin-8
(IL-8) was evaluated in bronchial epithelium derived cell lines, HS-24 and BET-1A, using�…

Materials and Methods Reagent Preparation Human recombinant IL-1/3 with a specific
activity of30 D/ng and murine anti-human monoclonal IL-{3 antibodies were the generous�…

We have tested the hypothesis that the bronchial epithelium has the capacity to generate
and release cytokines that could contribute to inflammatory events associated with�…

A number of novel chemotactic cytokines are becoming increasingly recognized as
important participants in the elicitation of specific inflammatory cells from the peripheral�…

Recent investigations have demonstrated interleukin-2 receptor (IL-2R) expression on both
human alveolar macrophages (AM�) and blood monocytes (PBM), but the function of these�…

The aims of this study were (a) to determine if rat alveolar type II (ATII) cells and human
pulmonary epithelial-derived cells (A549 cell line) could generate IL-6 in vitro,(b) to�…

Alveolar macrophages are the primary source of inflammatory cytokine production in the
lung. Both site-specific and differentiation-specific factors play a role in cytokine production�…

The effects of tumor necrosis factor-alpha (TNF-alpha) on interleukin-8 (IL-8) expression and
generation were examined in primary cultured human airway epithelial cells (HAEC) and a�…

The hallmark of acute inflammation in the lung is the presence ofa neutrophilic (PMN)
infiltration. Migration of these PMNs into the lung is dependent upon establishment of�…