Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen
detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting clustered�…

Rapid detection of nucleic acids is integral for clinical diagnostics and biotechnological
applications. We recently developed a platform termed SHERLOCK (specific high-sensitivity�…

Rapid and accurate identification of infectious diseases is essential to optimize clinical care
and guide infection control and public health interventions to limit disease spread both in�…

Nucleic acid detection is an important method for pathogen identification but can be
expensive, have variable sensitivity and specificity, and require substantial infrastructure�…

CRISPR-based nucleic acid detection methods are reported to facilitate rapid and sensitive
DNA detection. However, precise DNA detection at the single-base resolution and its wide�…

Mitigating global infectious disease requires diagnostic tools that are sensitive, specific, and
rapidly field deployable. In this study, we demonstrate that the Cas13-based SHERLOCK�…

The great majority of globally circulating pathogens go undetected, undermining patient care
and hindering outbreak preparedness and response. To enable routine surveillance and�…

Rapid detection of nucleic acids is integral to applications in clinical diagnostics and
biotechnology. We have recently established a CRISPR-based diagnostic platform that�…

Although polymerase chain reaction (PCR) is the most widely used method for DNA
amplification, the requirement of thermocycling limits its non-laboratory applications�…

For infectious diseases, rapid and accurate identification of the pathogen is critical for
effective management and treatment, but diagnosis remains challenging, particularly in�…