Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear
which subset of DCs performs this task. By using CD64 and MAR-1 staining, we reliably�…

In rodents, airway dendritic cells (DCs) capture inhaled Ag, undergo maturation, and migrate
to the draining mediastinal lymph nodes (MLN) to initiate the Ag-specific T cell response�…

Although dendritic cells (DCs) play an important role in sensitization to inhaled allergens,
their function in ongoing T helper (Th) 2 cell–mediated eosinophilic airway inflammation�…

It is unclear how Th2 immunity is induced in response to allergens like house dust mite
(HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent�…

Allergic asthma is one of the most common chronic diseases in western society,
characterized by variable airway obstruction, mucus hypersecretion and infiltration of the�…

Allergic asthma stems largely from the actions of T helper 2 (Th2) cells, but the pathways that
initiate Th2 responses to inhaled allergens are not fully understood. In the lung, there are�…

DCs are necessary and sufficient for induction of allergic airway inflammation. CD11b+ DCs
direct the underlying Th2 immunity, but debate surrounds the function of CD103+ DCs in�…

Dendritic cells (DCs) are crucial in determining the outcome of antigen encounter and
integrating signals derived from the antigen, its inflammatory context, and the host�…

An emerging concept is that different types of dendritic cells (DCs) initiate different immune
outcomes, such as tolerance vs inflammation. In this study, we have characterized the DCs�…

Highlights•Dendritic cells (DCs) are essential for inducing Th2 immunity to several
allergens.•Similar to other organs, lung DCs are a heterogeneous population of�…