Purpose: We performed this study to determine whether significant head trauma in human
adults can result in hippocampal cell loss, particularly in hilar (polymorph) and CA3 neurons�…

Whether hippocampal neuron loss and/or hippocampal sclerosis is the 'cause'or
'consequence'of seizures has been a fundamental question in human epilepsy studies for�…

Prolonged early‐life seizures are considered potential risk factors for later epilepsy
development, but mediators of this process remain largely unknown. Seizure‐induced�…

Posttraumatic epilepsy is a common consequence of traumatic brain injury in humans. Major
predictors for the development of posttraumatic epilepsy include the severity of injury and�…

Epilepsy is a common outcome of traumatic brain injury (TBI), but the mechanisms of
posttraumatic epileptogenesis are poorly understood. One clue is the occurrence of�…

Despite intensive study, the neurobiological basis of epilepsy and persistent memory
impairment following traumatic head injury remains unknown. Since abnormalities of the�…

Objective: To determine if posttraumatic nonconvulsive electrographic seizures result in long-
term brain atrophy. Methods: Prospective continuous EEG (cEEG) monitoring was done in�…

A retrospective study was carried out to determine whether a prior cerebral injury or medical
illness was associated with hippocampal sclerosis in intractable, surgically treated temporal�…

Hippocampal sclerosis describes a pattern of neuronal loss and gliosis involving the medial
temporal structures most often encountered in patients with epilepsy. It is still a matter for�…

Epilepsy complicates severe head trauma. Development of persistent seizures appears to
correlate with the extent of trauma. Although early reports suggested that prophylactic�…