Wnts are lipid-modified morphogens that play critical roles in development principally
through engagement of Frizzled receptors. The 3.25 angstrom structure of Xenopus Wnt8�…

Wnt signaling plays fundamental roles in organogenesis, tissue regeneration and cancer,
but high-resolution structural information of mammalian Wnt proteins is lacking. We solved a�…

INTRODUCTION Wnt signaling is an ancient signaling pathway that has accompanied the
emergence of metazoans and is key to many developmental, physiological, and disease�…

Secreted Wnt lipoproteins are cysteine-rich and lipid-modified morphogens that bind to the
Frizzled (FZD) receptor and LDL receptor-related protein 6 (LRP6). Wnt engages FZD�…

Frizzled (FZD) receptors mediate Wnt signaling in diverse processes ranging from bone
growth to stem cell activity. Moreover, high FZD receptor expression at the cell surface�…

Wnt-Frizzled (Fz) signaling pathways play recurring important roles during the development
and homeostasis of vertebrates and invertebrates. Fz receptors can signal through β-catenin�…

Members of the Frizzled family of seven-pass transmembrane proteins serve as receptors for
Wnt signalling proteins. Wnt proteins have important roles in the differentiation and�…

In Xenopus laevis embryos, the Wingless/Wnt-1 subclass of Wnt molecules induces axis
duplication, whereas the Wnt-5A subclass does not. This difference could be explained by�…

Wnts are secreted growth factors that have critical roles in cell fate determination and stem
cell renewal. The Wnt/β-catenin pathway is initiated by binding of a Wnt protein to a Frizzled�…

Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential
regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains�…