Systemic levels of proinflammatory cytokines such as interleukin-6 (IL-6) increase in old age
and may contribute to neural atrophy in humans. We investigated IL-6 associations with age�…

Higher systemic levels of the proinflammatory cytokine interleukin-6 (IL-6) were found to be
associated with lower gray matter volume and tissue density in old rhesus macaques. This�…

Abstract Interleukin-6 (IL-6) is a pro-inflammatory cytokine produced by immune cells and
other cell types such as microglia throughout the brain. Higher levels of IL-6 in older adults�…

High levels of Interleukin-6 (IL-6) are associated with an increased risk of dementia in the
elderly and can increase neuroinflammation in mice. Dementia is more frequent in females�…

We aimed to investigate if trajectory components (baseline level, slope, and variability) of
peripheral interleukin-6 (IL-6) over time were related to cognitive impairment and smaller�…

The aim of this investigation was to determine whether circulating inflammatory biomarkers c-
reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin (ACT) were related�…

Astrocytes, microglia, and neurons express the cytokine interleukin-6 (IL-6), which in the
brain has been suggested to reduce food intake, inhibit memory and learning, cause�…

BACKGROUND: Converging animal findings suggest that higher peripheral levels of
inflammation are associated with activation of central inflammatory mechanisms that result in�…

The aged rhesus macaque exhibits brain atrophy and behavioral deficits similar to normal
aging in humans. Here we studied the association between cognitive and motor�…

Ageing displays a low-grade pro-inflammatory profile in blood and the brain. Accumulation
of pro-inflammatory cytokines, microglia activation and volumetric changes in the brain�…