Inspiratory rhythm generation is stabilized by Ih
NJ Burgraff, RS Phillips, LJ Severs…�- Journal of�…, 2022 - journals.physiology.org
Cellular and network properties must be capable of generating rhythmic activity that is both
flexible and stable. This is particularly important for breathing, a rhythmic behavior that�…
flexible and stable. This is particularly important for breathing, a rhythmic behavior that�…
Sigh breathing rhythm depends on intracellular calcium oscillations in a population of inspiratory rhythmogenic preB�tzinger complex neurons in mice
DS Borrus, CJ Grover, GDC Smith, CA Del Negro�- bioRxiv, 2022 - biorxiv.org
The preB�tzinger Complex (preB�tC) of the lower brainstem generates two breathing-
related rhythms: one for inspiration on a timescale of seconds and another that produces�…
related rhythms: one for inspiration on a timescale of seconds and another that produces�…
[HTML][HTML] β-noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro
JC Viemari, AJ Garcia III, A Doi, G Elsen…�- Frontiers in Neural�…, 2013 - frontiersin.org
The pre-B�tzinger complex (preB�tC), an area that is critical for generating breathing
(eupnea), gasps and sighs is continuously modulated by catecholamines. These amines�…
(eupnea), gasps and sighs is continuously modulated by catecholamines. These amines�…
Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre-B�tzinger complex in vitro
H Koizumi, JC Smith�- Journal of Neuroscience, 2008 - Soc Neuroscience
A central problem in analyzing neural circuit function is establishing how intrinsic neuronal
conductances contribute to the generation of network activity. We used real-time calcium�…
conductances contribute to the generation of network activity. We used real-time calcium�…
[HTML][HTML] Chronic intermittent hypoxia differentially impacts different states of inspiratory activity at the level of the preB�tzinger complex
AJ Garcia III, T Dashevskiy, MA Khuu…�- Frontiers in�…, 2017 - frontiersin.org
The preB�tzinger complex (preB�tC) is a medullary brainstem network crucially involved in
the generation of different inspiratory rhythms. In the isolated brainstem slice, the preB�tC�…
the generation of different inspiratory rhythms. In the isolated brainstem slice, the preB�tC�…
[HTML][HTML] Emergent elements of inspiratory rhythmogenesis: network synchronization and synchrony propagation
S Ashhad, JL Feldman�- Neuron, 2020 - cell.com
We assessed the mechanism of mammalian breathing rhythmogenesis in the preB�tzinger
complex (preB�tC) in vitro, where experimental tests remain inconsistent with hypotheses of�…
complex (preB�tC) in vitro, where experimental tests remain inconsistent with hypotheses of�…
State-dependent contribution of the hyperpolarization-activated Na+/K+ and persistent Na+ currents to respiratory rhythmogenesis in vivo
G Montandon, RL Horner�- Journal of Neuroscience, 2013 - Soc Neuroscience
How rhythms are generated by neuronal networks is fundamental to understand rhythmic
behaviors such as respiration, locomotion, and mastication. Respiratory rhythm is generated�…
behaviors such as respiration, locomotion, and mastication. Respiratory rhythm is generated�…
Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preB�tzinger complex
DS Borrus, MK Stettler, CJ Grover…�- The Journal of�…, 2024 - Wiley Online Library
Breathing behaviour involves the generation of normal breaths (eupnoea) on a timescale of
seconds and sigh breaths on the order of minutes. Both rhythms emerge in tandem from a�…
seconds and sigh breaths on the order of minutes. Both rhythms emerge in tandem from a�…
[HTML][HTML] Opioids modulate an emergent rhythmogenic process to depress breathing
X Sun, C Th�rn P�rez, N Halemani D, XM Shao…�- Elife, 2019 - elifesciences.org
How mammalian neural circuits generate rhythmic activity in motor behaviors, such as
breathing, walking, and chewing, remains elusive. For breathing, rhythm generation is�…
breathing, walking, and chewing, remains elusive. For breathing, rhythm generation is�…
Interdependence of cellular and network properties in respiratory rhythm generation
RS Phillips, NA Baertsch�- Proceedings of the National�…, 2024 - National Acad Sciences
How breathing is generated by the preB�tzinger complex (preB�tC) remains divided
between two ideological frameworks, and a persistent sodium current (INaP) lies at the heart�…
between two ideological frameworks, and a persistent sodium current (INaP) lies at the heart�…