Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis
HL Neville-Webbe, NA Cross, CL Eaton…�- Breast cancer research�…, 2004 - Springer
Advanced breast cancer is often associated with metastatic bone disease, causing a number
of serious complications for the patients such as hypercalceamia, pain, nerve compression�…
of serious complications for the patients such as hypercalceamia, pain, nerve compression�…
Osteoprotegerin (OPG) Expression by Breast Cancer Cells in vitro and Breast Tumours in vivo – A Role in Tumour Cell Survival?
In addition to its role in bone turnover, osteoprotegerin (OPG) has been reported to bind to
and inhibit Tumour necrosis factor-related apoptosis inducing ligand (TRAIL). TRAIL is�…
and inhibit Tumour necrosis factor-related apoptosis inducing ligand (TRAIL). TRAIL is�…
Osteoprotegerin production by breast cancer cells is suppressed by dexamethasone and confers resistance against TRAIL‐induced apoptosis
TD Rachner, P Benad, M Rauner…�- Journal of cellular�…, 2009 - Wiley Online Library
Osteoprotegerin (OPG) is a decoy receptor for receptor activator of NF‐κB ligand (RANKL)
and TNF‐related apoptosis‐inducing ligand (TRAIL). While RANKL is essential for�…
and TNF‐related apoptosis‐inducing ligand (TRAIL). While RANKL is essential for�…
[HTML][HTML] Osteoprotegerin in breast cancer: beyond bone remodeling
M Weichhaus, STM Chung, L Connelly�- Molecular cancer, 2015 - Springer
Osteoprotegerin (OPG) is a secreted protein and member of the Tumor Necrosis Factor
(TNF) Receptor superfamily. OPG has been well characterized as a regulator of bone�…
(TNF) Receptor superfamily. OPG has been well characterized as a regulator of bone�…
Osteoprotegerin expression in triple‐negative breast cancer cells promotes metastasis
M Weichhaus, P Segaran, A Renaud, D Geerts…�- Cancer�…, 2014 - Wiley Online Library
Osteoprotegerin (OPG) is a secreted member of the tumor necrosis factor (TNF) receptor
superfamily that has been well characterized as a negative regulator of bone remodeling�…
superfamily that has been well characterized as a negative regulator of bone remodeling�…
Osteoprotegrin and the bone homing and colonization potential of breast cancer cells
Breast cancer cells preferentially metastasize to bone, leading to the formation of primarily
osteolytic lesions. Osteoprotegerin (OPG) plays multifactorial roles in the development of�…
osteolytic lesions. Osteoprotegerin (OPG) plays multifactorial roles in the development of�…
Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor κB ligand (RANKL) in human breast�…
C Van Poznak, SS Cross, M Saggese…�- Journal of clinical�…, 2006 - jcp.bmj.com
Background: Osteoprotegerin (OPG) is involved in the regulation of bone turnover through
binding to the receptor activator of nuclear factor κB ligand (RANKL), and has also been�…
binding to the receptor activator of nuclear factor κB ligand (RANKL), and has also been�…
Human bone marrow stromal cells protect prostate cancer cells from TRAIL‐induced apoptosis
Tumor‐derived OPG has recently been shown to protect prostate cancer cells from
apoptosis. This study has confirmed that bone marrow stromal cell‐derived OPG also�…
apoptosis. This study has confirmed that bone marrow stromal cell‐derived OPG also�…
[HTML][HTML] Osteoprotegerin: relationship to breast cancer risk and prognosis
D Geerts, C Chopra, L Connelly�- Frontiers in Oncology, 2020 - frontiersin.org
Osteoprotegerin (OPG) is a secreted member of the Tumor Necrosis Factor (TNF) receptor
superfamily (TNFRSF11B), that was first characterized and named for its protective role in�…
superfamily (TNFRSF11B), that was first characterized and named for its protective role in�…
[HTML][HTML] Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis
S Goswami, N Sharma-Walia�- BMC cancer, 2015 - Springer
Background Osteoprotegerin (OPG) is a glycoprotein that has multifaceted role and is
associated with several cancer malignancies like that of bladder carcinoma, gastric�…
associated with several cancer malignancies like that of bladder carcinoma, gastric�…