GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatment
MBN Gabe, K Skov-Jeppesen, LS Gasbjerg…�- Pharmacological�…, 2022 - Elsevier
The intestinal hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-
like peptide-2 (GLP-2) are key regulators of postprandial bone turnover in humans. We�…
like peptide-2 (GLP-2) are key regulators of postprandial bone turnover in humans. We�…
GLP-2 and GIP exert separate effects on bone turnover: a randomized, placebo-controlled, crossover study in healthy young men
K Skov-Jeppesen, MS Svane, C Martinussen…�- Bone, 2019 - Elsevier
Abstract Background Glucagon-like peptide-2 (GLP-2) and glucose-dependent
insulinotropic polypeptide (GIP) both inhibit bone resorption in humans but the underlying�…
insulinotropic polypeptide (GIP) both inhibit bone resorption in humans but the underlying�…
Separate and combined effects of GIP and GLP-1 infusions on bone metabolism in overweight men without diabetes
NC Bergmann, A Lund, LS Gasbjerg…�- The Journal of�…, 2019 - academic.oup.com
Context The gut-derived incretin hormones glucose-dependent insulinotropic polypeptide
(GIP) and glucagon-like peptide 1 (GLP-1) have been suggested to play a role in bone�…
(GIP) and glucagon-like peptide 1 (GLP-1) have been suggested to play a role in bone�…
The role of endogenous GIP and GLP-1 in postprandial bone homeostasis
MM Helsted, LS Gasbjerg, AR Lanng, NC Bergmann…�- Bone, 2020 - Elsevier
The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-
like peptide 1 (GLP-1) are well known for their insulinotropic effects and they are thought to�…
like peptide 1 (GLP-1) are well known for their insulinotropic effects and they are thought to�…
GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP (3–30) NH2
LS Gasbjerg, B Hartmann, MB Christensen, AR Lanng…�- Bone, 2020 - Elsevier
Infusion of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP)
suppresses the bone resorption marker carboxy-terminal type 1 collagen crosslinks (CTX)�…
suppresses the bone resorption marker carboxy-terminal type 1 collagen crosslinks (CTX)�…
The gut-bone axis in diabetes
Abstract Purpose of Review To describe recent advances in the understanding of how gut-
derived hormones regulate bone homeostasis in humans with emphasis on�…
derived hormones regulate bone homeostasis in humans with emphasis on�…
Effects of gastric inhibitory polypeptide, glucagon‐like peptide‐1 and glucagon‐like peptide‐1 receptor agonists on Bone Cell Metabolism
MSS Hansen, M Tencerova, J Fr�lich…�- Basic & Clinical�…, 2018 - Wiley Online Library
The relationship between gut and skeleton is increasingly recognized as part of the
integrated physiology of the whole organism. The incretin hormones gastric inhibitory�…
integrated physiology of the whole organism. The incretin hormones gastric inhibitory�…
The antiresorptive effect of GIP, but not GLP‐2, is preserved in patients with hypoparathyroidism—a randomized crossover study
K Skov‐Jeppesen, N Hepp, J Oeke…�- Journal of Bone and�…, 2020 - academic.oup.com
Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐2 (GLP‐2)
are gut hormones secreted postprandially. In healthy humans, both hormones decrease�…
are gut hormones secreted postprandially. In healthy humans, both hormones decrease�…
Effects of exogenous GIP and GLP-2 on bone turnover in individuals with type 2 diabetes
K Skov-Jeppesen, CB Christiansen…�- The Journal of�…, 2024 - academic.oup.com
Context Individuals with type 2 diabetes (T2D) have an increased risk of bone fractures
despite normal or increased bone mineral density. The underlying causes are not well�…
despite normal or increased bone mineral density. The underlying causes are not well�…
A Pilot Study Showing Acute Inhibitory Effect of GLP 1 on the Bone Resorption Marker CTX in Humans
A Nissen, S Marstrand, K Skov Jeppesen…�- Journal of Bone and�…, 2019 - academic.oup.com
Bones have been suggested to be a target for glucagon like peptide 1 (GLP 1); however,
studies of the effects on human bones so far have given diverging results. We hypothesized�…
studies of the effects on human bones so far have given diverging results. We hypothesized�…