Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct
effects on naive CD8+ T cells to reduce intrinsic functionality, but the precise nature of this�…

The number of memory phenotype CD8 T cells increases dramatically with aging in both
humans and mice. However, the mechanism for this is unknown. The prevailing hypothesis�…

Age-related declines in immune function have an impact on both primary and memory
responses. In this study, we have examined the ability of naive CD4 T cells from young and�…

Naive T cell responses are eroded with aging. We and others have recently shown that
unimmunized old mice lose≥ 70% of Ag-specific CD8 T cell precursors and that many of the�…

When encountering foreign antigens, na�ve T cells become activated and differentiate into
effector and memory T cells. They represent therefore the primary source to mount an�…

A decline in T‐cell responses and a switch to memory T‐cell predominance occur with
aging. We have used the T‐cell receptor (TCR) transgenic mouse model to study age�…

CD4 T cells, and especially T follicular helper cells, are critical for the generation of a robust
humoral response to an infection or vaccination. Importantly, immunosenescence affects�…

Survival and homeostatic division of naive CD4 T cells is regulated by the cellular and non-
cellular milieu and together these processes ensure that a population of naive CD4 T cells�…

Memory T cells can be classified as central memory (TCM, CD45RAnegCCR7+), effector
memory (TEM, CD45RAnegCCR7neg), and terminally differentiated cells (TTD, CD45RA+�…

With age, T-cell generation from the thymus is much reduced, yet a substantial na�ve T-cell
pool is maintained even in aged animals, suggesting that na�ve T cells either persist longer�…