The diurnal variation in bone resorption markers is poorly understood and may contain
essential information about regulation of bone resorption. To explore the acute regulation of�…

The impact of antidiabetic drugs on bone metabolism is drawing increasing attention due to
the discovery of a correlation between type 2 diabetes mellitus (T2DM) and osteoporosis�…

Background In recent years the interest on the relationship of gut hormones to bone
processes has increased and represents one of the most interesting aspects in skeletal�…

Bone resorption shows a circadian rhythm in human subjects, but the physiological
mechanisms underlying this rhythm are unknown. We compared the circadian rhythm of�…

There is growing recognition of the role of diet and physical activity in modulating bone
mineral density, bone mineral content, and remodeling, which in turn can impact bone�…

Diabetes mellitus and osteoporosis are closely related and have complex influencing
factors. The impact of anti-diabetic drugs on bone metabolism has received more and more�…

Objective Biochemical markers of bone turnover exhibit circadian rhythms with the peak
during the night/early morning and the nadir in the late afternoon. The nocturnal increase in�…

Insulin-like growth factor-I (IGF-I) is a nutritionally dependent bone trophic hormone which
stimulates osteoblast function and collagen synthesis in vivo and in vitro. We hypothesized�…

Osteoporosis mainly affects postmenopausal women and older men. Gastrointestinal
hormones released after meal ingestion, such as glucose‐dependent insulinotropic peptide�…

The uncarboxylated form (ucOC), but not the γ-carboxylated form (GlaOC), of the bone-
derived protein osteocalcin stimulates insulin secretion and regulates energy metabolism in�…