[HTML][HTML] Gut hormones and their effect on bone metabolism. Potential drug therapies in future osteoporosis treatment

SP Schiellerup, K Skov-Jeppesen…�- Frontiers in�…, 2019 - frontiersin.org
Bone homeostasis displays a circadian rhythm with increased resorption during the night
time as compared to day time, a difference that seems—at least partly—to be caused by food�…

Octreotide abolishes the acute decrease in bone turnover in response to oral glucose

JA Clowes, HC Allen, DM Prentis…�- The Journal of�…, 2003 - academic.oup.com
Feeding or oral intake of glucose results in an acute suppression of bone turnover. This
does not appear to be mediated by insulin. Several gastrointestinal hormones modulate�…

Effect of feeding on bone turnover markers and its impact on biological variability of measurements

JA Clowes, RA Hannon, TS Yap, NR Hoyle…�- Bone, 2002 - Elsevier
Bone turnover markers are subject to day-to-day and within-day variability, which may
influence clinical interpretation. We examined the effect of fasting vs. feeding on the�…

Feeding and bone

JS Walsh, DB Henriksen�- Archives of Biochemistry and Biophysics, 2010 - Elsevier
Diurnal variation in bone turnover is responsive to feeding and fasting, and feeding results in
an acute decrease in bone resorption. These responses may be governed by multiple�…

GLP-1 receptor agonist treatment increases bone formation and prevents bone loss in weight-reduced obese women

EW Iepsen, JR Lundgren, B Hartmann…�- The Journal of�…, 2015 - academic.oup.com
Context: Recent studies indicate that glucagon-like peptide (GLP)-1 regulates bone
turnover, but the effects of GLP-1 receptor agonists (GLP-1 RAs) on bone in obese weight�…

Effects of glucose-dependent insulinotropic peptide on osteoclast function

Q Zhong, T Itokawa, S Sridhar…�- American Journal�…, 2007 - journals.physiology.org
Acute nutrient ingestion leads to a rapid inhibition of bone resorption while effects on makers
of bone formation are less marked or absent, suggesting that there is a transient shift toward�…

Potential role of pancreatic and enteric hormones in regulating bone turnover

JA Clowes, S Khosla, R Eastell�- Journal of Bone and Mineral�…, 2005 - academic.oup.com
ADEQUATE NUTRIENT INTAKE and normal gastrointesti-nal function are essential to bone
health. Disorders of nutrient supply caused by either abnormal intake (eg, anorexia nervosa�…

Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion

A Mizokami, Y Yasutake, S Higashi…�- Bone, 2014 - Elsevier
Uncarboxylated osteocalcin (GluOC), a bone-derived hormone, regulates energy
metabolism by stimulating insulin secretion and pancreatic β-cell proliferation. We�…

Gastric banding induces negative bone remodelling in the absence of secondary hyperparathyroidism: potential role of serum C telopeptides for follow-up

V Giusti, C Gasteyger, M Suter, E Heraief…�- International journal of�…, 2005 - nature.com
OBJECTIVE: Data about the consequences of laparoscopic adjustable gastric banding
(LAGB) on phospho-calcic and bone metabolism remain scarce. SUBJECTS: We studied a�…

The murine glucagon-like peptide-1 receptor is essential for control of bone resorption

C Yamada, Y Yamada, K Tsukiyama, K Yamada…�- …, 2008 - academic.oup.com
Gastrointestinal hormones including gastric inhibitory polypeptide (GIP), glucagon-like
peptide (GLP)-1, and GLP-2 are secreted immediately after meal ingestion, and GIP and�…