Microglia are increasingly implicated as a source of non‐neural regulation of postnatal
neurogenesis and neuronal development. To evaluate better the contributions of microglia�…

Microglia play important roles in the damaged or degenerating adult nervous system.
However, the role of microglia in embryonic brain development is still largely�…

Neurogenesis must be properly regulated to ensure that cell production does not exceed the
requirements of the growing cerebral cortex, yet our understanding of mechanisms that�…

Highlights•Glial cells are central components of all neurogenic niches.•Certain glial cells act
as neural stem cells while others regulate neural stem cells.•A subset of embryonic radial�…

Recent reports have supported the existence of neural stem cells in the adult mammalian
CNS. Important features of such cells are self-renewal and multipotency, ie, they can give�…

Adult neurogenesis was one of the most important discoveries of the last century, helping us
to better understand brain function. Researchers recently discovered that microglia play an�…

Despite intense study, the precise origin and cell lineage of microglia, the resident
mononuclear phagocytes of the nervous system, are still a matter for debate. Unlike�…

The modern concept of neurogenesis in the adult brain is predicated on the premise that
multipotent glial cells give rise to new neurons throughout life. Although extensive evidence�…

Subventricular zone (SVZ) neural stem cells (NSCs) are the cornerstone of the perinatal
neurogenic niche. Microglia are immune cells of the nervous system that are enriched in the�…

Although microglia have long been considered as brain resident immune cells, increasing
evidence suggests that they also have physiological roles in the development of the normal�…