A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage
Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives
presented by the antigen-presenting molecule MR1. Here we defined three developmental�…
presented by the antigen-presenting molecule MR1. Here we defined three developmental�…
A divergent transcriptional landscape underpins the development and functional branching of MAIT cells
MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune
system. These cells develop intrathymically through a three-stage process, but the events�…
system. These cells develop intrathymically through a three-stage process, but the events�…
[HTML][HTML] Single-cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize
microbial vitamin B metabolites and have emerging roles in infectious disease�…
microbial vitamin B metabolites and have emerging roles in infectious disease�…
[HTML][HTML] Activation of human mucosal-associated invariant T cells induces CD40L-dependent maturation of monocyte-derived and primary dendritic cells
M Salio, O Gasser, C Gonzalez-Lopez…�- The Journal of�…, 2017 - journals.aai.org
Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize intermediates
of the vitamin B2 biosynthetic pathway presented by the monomorphic MR1 molecule. It�…
of the vitamin B2 biosynthetic pathway presented by the monomorphic MR1 molecule. It�…
[HTML][HTML] Stepwise development of MAIT cells in mouse and human
Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features:
an invariant T cell receptor (TCR) α (iTCRα) chain and restriction by the nonpolymorphic�…
an invariant T cell receptor (TCR) α (iTCRα) chain and restriction by the nonpolymorphic�…
[HTML][HTML] Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain�…
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain�…
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
R Reantragoon, AJ Corbett, IG Sakala…�- Journal of Experimental�…, 2013 - rupress.org
Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor
(TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the�…
(TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the�…
[HTML][HTML] TCR-or cytokine-activated CD8+ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses
R Lamichhane, M Schneider, SM de la Harpe…�- Cell reports, 2019 - cell.com
Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin�…
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin�…
The biology and functional importance of MAIT cells
DI Godfrey, HF Koay, J McCluskey, NA Gherardin�- Nature immunology, 2019 - nature.com
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their�…
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their�…
Mucosal-associated invariant T cells: unconventional development and function
L Le Bourhis, L Guerri, M Dusseaux, E Martin…�- Trends in�…, 2011 - cell.com
Mucosal-associated invariant T (MAIT) cells are a population of T cells that display a semi-
invariant T cell receptor (TCR) and are restricted by the evolutionarily conserved major�…
invariant T cell receptor (TCR) and are restricted by the evolutionarily conserved major�…
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