A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

HF Koay, NA Gherardin, A Enders, L Loh…�- Nature�…, 2016 - nature.com
Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives
presented by the antigen-presenting molecule MR1. Here we defined three developmental�…

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

HF Koay, S Su, D Amann-Zalcenstein, SR Daley…�- Science�…, 2019 - science.org
MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune
system. These cells develop intrathymically through a three-stage process, but the events�…

[HTML][HTML] Single-cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation

CK Vorkas, C Krishna, K Li, J Aube…�- The Journal of�…, 2022 - journals.aai.org
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize
microbial vitamin B metabolites and have emerging roles in infectious disease�…

[HTML][HTML] Activation of human mucosal-associated invariant T cells induces CD40L-dependent maturation of monocyte-derived and primary dendritic cells

M Salio, O Gasser, C Gonzalez-Lopez…�- The Journal of�…, 2017 - journals.aai.org
Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize intermediates
of the vitamin B2 biosynthetic pathway presented by the monomorphic MR1 molecule. It�…

[HTML][HTML] Stepwise development of MAIT cells in mouse and human

E Martin, E Treiner, L Duban, L Guerri, H Laude…�- PLoS�…, 2009 - journals.plos.org
Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features:
an invariant T cell receptor (TCR) α (iTCRα) chain and restriction by the nonpolymorphic�…

[HTML][HTML] Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity

LC Garner, A Amini, MEB FitzPatrick, MJ Lett…�- Nature�…, 2023 - nature.com
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain�…

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

R Reantragoon, AJ Corbett, IG Sakala…�- Journal of Experimental�…, 2013 - rupress.org
Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor
(TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the�…

[HTML][HTML] TCR-or cytokine-activated CD8+ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses

R Lamichhane, M Schneider, SM de la Harpe…�- Cell reports, 2019 - cell.com
Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin�…

The biology and functional importance of MAIT cells

DI Godfrey, HF Koay, J McCluskey, NA Gherardin�- Nature immunology, 2019 - nature.com
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their�…

Mucosal-associated invariant T cells: unconventional development and function

L Le Bourhis, L Guerri, M Dusseaux, E Martin…�- Trends in�…, 2011 - cell.com
Mucosal-associated invariant T (MAIT) cells are a population of T cells that display a semi-
invariant T cell receptor (TCR) and are restricted by the evolutionarily conserved major�…