Context: The sensitivity of the placenta to maternal insulin remains controversial. Early
pregnancy may be a time of increased placental sensitivity to maternal insulin because�…

Placentas from gestational diabetes (GDM) suffer from structural and functional changes
including overgrowth. That is why we aimed to study [3 H]-leucine incorporation into protein�…

Placental fetal metabolic relationships are complex and dynamic. For example, the placenta
consumes glucose as well as transports it to the fetus, thus regulating fetal glucose supply�…

Gestational diabetes mellitus (GDM) is the most frequent pathophysiological state of
pregnancy, which in many cases produces fetuses with macrosomia, requiring increased�…

Diabetes mellitus (DM) is a health condition characterized by hyperglycemia over a
prolonged period. There are three main types of DM: DM type 1 (DM1), DM2 and gestational�…

A physiological state of insulin resistance is required to preferentially direct maternal
nutrients toward the feto-placental unit, allowing adequate growth of the fetus. When women�…

In pregnant women with type 1 diabetes, suboptimal glucose control in the first trimester is a
strong predictor for giving birth to a large fetus. However, the mechanisms underlying this�…

Normal placental function is essential for optimal fetal growth. Transport of glucose from
mother to fetus is critical for fetal nutrient demands and can be stored in the placenta as�…

It is well understood that sex differences exist between females and males even before they
are born. These sex-dependent differences may contribute to altered growth and�…

Compelling epidemiological and animal experimental data demonstrate that
cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine�…