The ability to express or deplete proteins in living cells is crucial for the study of biological
processes. Viral vectors are often useful to deliver DNA constructs to cells that are difficult to�…

Lentiviral vectors are potent gene delivery vehicles that enable stable expression of
transgenes in both dividing and post-mitotic cells. Development of lentiviral vectors�…

The capacity to efficiently transduce nondividing cells, shuttle large genetic payloads, and
maintain stable long-term transgene expression are attributes that have brought lentiviral�…

Over the years, many different viral vector systems have been developed to take advantage
of the specific biological properties and tropisms of a large number of mammalian viruses�…

Lentiviral vectors are the most frequently used tool to stably transfer and express genes in
the context of gene therapy for monogenic diseases. The vast majority of clinical�…

Lentiviral vectors have been successfully used in the clinic and they are increasingly being
used for nonclinical applications. They are capable of stably transducing a broad range of�…

First described about a decade ago, lentiviral vectors ('lentivectors') have emerged as potent
and versatile tools of gene transfer for basic and applied research and offer exciting�…

Functional gene analysis requires the possibility of overexpression, as well as
downregulation of one, or ideally several, potentially interacting genes. Lentiviral vectors are�…

Over the past decades, lentiviral vectors have evolved as a benchmark tool for stable gene
transfer into cells with a high replicative potential. Their relatively flexible genome and ability�…

RNA interference is an evolutionarily conserved process of gene silencing that in plants
serves as a natural defense mechanism against exogenous viral agents. RNA interference�…