Colitis caused by Clostridium difficile infection is a growing cause of human morbidity and
mortality, especially after antibiotic use in health care settings. The natural immunity of�…

Clostridium difficile infection (CDI) is a toxin-mediated intestinal disease. Toxin A, toxin B
and binary toxin are believed to be responsible for the pathogenesis of CDI, which is�…

Clostridium difficile infection (CDI) is the number one hospital-acquired infection in the
United States. CDI is more common and severe in inflammatory bowel disease patients�…

Background Clostridium difficile is a leading cause of nosocomial infection. The role of
cytokine interleukin-27 (IL-27) in the immunopathology of C. difficile infection (CDI) remains�…

Clostridium difficile is currently the leading cause of hospital-acquired infections in the
United States. Here, we observed increased interleukin 23 (IL-23) protein levels in human�…

There are major gaps in our understanding of the immunopathogenesis of Clostridium
difficile infections (CDIs). In this study, 36 different biomarkers were examined in the stools of�…

Th 17 cells have been implicated in the pathogenesis of colitis; however, a cellular
mechanism by which colitogenic Th17 immunity arises in vivo remains unclear. In this study�…

In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-
17F, and IL-25 in the host defense against infection and in inflammatory diseases; however�…

Our objective was to determine the role of the inflammatory cytokine interleukin‐23 (IL‐23) in
promoting neutrophil recruitment, inflammatory cytokine expression and intestinal�…

The cytokines IL-17A and IL-17F have 50% amino-acid identity and bind the same receptor;
however, their functional differences have remained obscure. Here we found that Il17f�…