Brain inflammation is a major factor in epilepsy, but the impact of specific inflammatory
mediators on neuronal excitability is incompletely understood. Using models of acute and�…

Approximately 30% of epilepsy patients experience seizures that are not controlled by the
available drugs. Moreover, these drugs provide mainly a symptomatic treatment since they�…

Epilepsy is a chronic disorder of the nervous system characterized by recurrent seizures.
Inflammation is one of the six major causes of epilepsy, and its role in the pathogenesis of�…

Maroso M., Balosso S., Ravizza T., Liu J., Bianchi ME, Vezzani A.(Mario Negri Institute for
Pharmacological Research, Milano; and San Raffaele University and Research Institute�…

Highlights•Inflammatory molecules have neuromodulatory effects distinct from their immune
functions.•Inflammatory molecules contribute to neuronal hyperexcitability underlying�…

A large set of inflammatory molecules and their receptors are induced in epileptogenic foci
of patients with pharmacoresistant epilepsies of structural etiologies or with refractory status�…

Temporal Lobe Epilepsy (TLE) is the most common form of human epilepsy and available
treatments with antiepileptic drugs are not disease-modifying therapies. The�…

Recent experimental studies and pathological analyses of patient brain tissue samples with
refractory epilepsy suggest that inflammatory processes and neuroinflammation plays a key�…

Increasing evidence supports the involvement of immune and inflammatory processes in the
etiopathogenesis of seizures. In particular, activation of innate immune mechanisms and the�…

Understanding the interplay between the innate immune system, neuroinflammation, and
epilepsy might offer a novel perspective in the quest of exploring new treatment strategies�…